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Celecoxib is approved and used for the following medical treatments:
Rheumatoid Arthritis (RA)
Juvenile Rheumatoid Arthritis (JRA) in patients 2 years and older
Ankylosing Spondylitis (AS)
Acute Pain (AP)
Primary Dysmenorrhea (PD)
Familial Adenomatous Polyposis (FAP)-adjunct to usual care)
Celebrex is a Cyclooxygenase-2 COX-2 Inhibitors used in the treatment of pain, inflammation, and stiffness of arthritis.
Brand Names for Celecoxib:
Algybrex (Northia Medicinales)
Celcox (Trima Pharmaceuticals)
Celedol (Ipca Laboratories)
Celib (Unichem Laboratories)
Cloxib (Klonal Laboratorios)
Coxel (Beta Laboratorios)
Coxtenk (Biotenk Laboratorio Farmaceutico)
Niflam (Roemmers Laboratorios)
Orthocel (Biochem Pharmaceutical Industries)
Radicacine (Panalab Laboratorios)
Tisorek (Microsules y Bernabo)
Ultracele (Ultratech India)
Zycel (Zydus Cadila)
The following adverse reactions occurred in 0.1 – 1.9% of patients treated with CELEBREX (100 – 200 mg twice daily or 200 mg once daily):
Gastrointestinal: Constipation, diverticulitis, dysphagia, eructation, esophagitis, gastritis, gastroenteritis, gastroesophageal reflux, hemorrhoids, hiatal hernia, melena, dry mouth, stomatitis, tenesmus, vomiting
Cardiovascular: Aggravated hypertension, angina pectoris, coronary artery disorder, myocardial infarction
General: Allergy aggravated, allergic reaction, chest pain, cyst NOS, edema generalized, face edema, fatigue, fever, hot flushes, influenza-like symptoms, pain, peripheral pain
Central, peripheral nervous system: Leg cramps, hypertonia, hypoesthesia, migraine, paresthesia, vertigo
Hearing and vestibular: Deafness, tinnitus
Heart rate and rhythm: Palpitation, tachycardia
Liver and biliary: Hepatic function abnormal, SGOT increased, SGPT increased
Metabolic and nutritional: BUN increased, CPK increased, hypercholesterolemia, hyperglycemia, hypokalemia, NPN increased, creatinine increased, alkaline phosphatase increased, weight increased
Musculoskeletal: Arthralgia, arthrosis, myalgia, synovitis, tendinitis
Platelets (bleeding or clotting): Ecchymosis, epistaxis, thrombocythemia
Psychiatric: Anorexia, anxiety, appetite increased, depression, nervousness, somnolence
Respiratory: Bronchitis, bronchospasm, bronchospasm aggravated, coughing, dyspnea, laryngitis, pneumonia
Skin and appendages: Alopecia, dermatitis, photosensitivity reaction, pruritus, rash erythematous, rash maculopapular, skin disorder, skin dry, sweating increased, urticaria
Application site disorders: Cellulitis, dermatitis contact
Urinary: Albuminuria, cystitis, dysuria, hematuria, micturition frequency, renal calculus
The following serious adverse events (causality not evaluated) occurred in <0.1% of patients
Cardiovascular: Syncope, congestive heart failure, ventricular fibrillation, pulmonary embolism, cerebrovascular accident, peripheral gangrene, thrombophlebitis, vasculitis, deep venous thrombosis
Gastrointestinal: Intestinal obstruction, intestinal perforation, gastrointestinal bleeding, colitis with bleeding, esophageal perforation, pancreatitis, ileus
Liver and biliary: Cholelithiasis, hepatitis, jaundice, liver failure
Hemic and lymphatic: Thrombocytopenia, agranulocytosis,aplastic anemia, pancytopenia, leucopenia
Metabolic: Hypoglycemia, hyponatremia
Nervous: Ataxia, suicide, aseptic meningitis, ageusia, anosmia, fatal intracranial hemorrhage
Renal: Acute renal failure, interstitial nephritis
Skin: Erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis
General: Sepsis, sudden death, anaphylactoid reaction, angioedema
If you miss a dose of Celecoxib and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Generic Celebrex Warnings
NSAIDs, including CELEBREX, cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events.
CELEBREX may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. All nonsteroidal anti-inflammatory drugs (NSAIDs) may have a similar risk. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk.
CELEBREX is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
There are no studies in pregnant women. CELEBREX should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
No studies have been conducted to evaluate the effect of celecoxib on the closure of the ductus arteriosus in humans. Therefore, use of CELEBREX during the third trimester of pregnancy should be avoided.
The effects of CELEBREX on labor and delivery in pregnant women are unknown.
Caution should be exercised when CELEBREX is administered to a nursing woman.
Store away from heat, moisture, and light. Do not store in the bathroom. Keep Celecoxib out of the reach of children and away from pets.